Preparation of stable new polymorphic form of atorvastatin calcium
نویسندگان
چکیده
An efficient, simple, consistent and economic process for stable new polymorphic form of atorvastatin calcium (1) is described. The new polymorphic form of atorvastatin calcium (1) is characterizated by PXRD.
منابع مشابه
An improved kilogram-scale preparation of atorvastatin calcium
BACKGROUND If literature protocols are followed, conversion of an advanced ketal ester intermediate (available in kilogram quantities via a published Paal-Knorr synthesis) to cholesterol-lowering drug atorvastatin calcium is hampered by several process issues, particularly at the final stage where the hemi-calcium salt is obtained. RESULTS We developed a high-yielding synthesis of atorvastati...
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